One way to examine this comment is to survey all the climate niches around the world where people have made their homes. Yet a more personal level is recognized when individuals and their lives are examined. You can think about this and come up with examples from your surroundings where you live. I sometimes say, "It seems people, dogs and cats can live just about anywhere."
Take my situation. I come from a family that once was large, but normal expectant life has dwindled the number down. It seemed from my childhood up through mid-life I always had friends and acquaintances. Leaving active musical performances and retirement reduced the number of people in my life even further. In all of these changes, I am sure I still would have made new friends and acquaintances if not for the advent of my wife's serious cognitive disease.
One thing I have experienced is that people, family and friends, included, find dealing with my wife's illness difficult to navigate. Whether not knowing how to react or not knowing how to help or just feeling awkward in her presence, the result is the same: Isolation. There is no cure for Alzheimer's, Dementia, and Aphasia, so cursory visits to doctors only address other health issues as necessary. My wife had early onset, as in the well-known situation with Bruce Willis. From articles I have read, he has people who support and care for him, but as for my wife, she only has me.
We exist in a town where we wound up purely by chance and circumstances. We are "Strangers in a Strange Land."
Since her diagnosis and descent into her disease in the Fall of 2017, I have been her only 24/7 caregiver. I have made errors in judgment that has made things worse for me, but I can say I have grown accustomed to the life I am living. I have adapted, expect little, and just seem to drift aimlessly, not having any expectations of a better life.